Goh, Meeichyn Min, Kiyoon Kim, Young Ha Tae, Giyoong 2024-01-19T08:00:44Z 2024-01-19T08:00:44Z 2024-01-18 2024-01 2046-2069 https://pubs.kist.re.kr/handle/201004/112951 Osseointegration remains one of the major challenges in the success of bone-related implants. Recently, polyetheretherketone (PEEK) has emerged as an alternative material in orthopedic and dental applications due to its bone-mimicking mechanical properties. However, its bioinertness resulting in poor osseointegration has limited its potential application. So, the surface modification of PEEK with bone morphogenetic protein-2 (BMP-2) can be a potential approach for improving osseointegration. In this study, we proposed the chemical modification of heparin onto PEEK through an environmentally benign method to exploit the BMP-2 binding affinity of heparin. The heparin was successfully functionalized on the PEEK surface via a combination of ozone and UV treatment without using organic solvents or chemicals. Furthermore, BMP-2 was efficiently immobilized on PEEK and exhibited a sustained release of BMP-2 compared to the pristine PEEK with enhancement of bioactivity in terms of proliferation as well as osteogenic differentiation of MG-63. The significant synergistic effect of BMP-2 and heparin grafting on osteogenic differentiation of MG-63 was observed. Overall, we demonstrated a relatively safe method where no harsh chemical reagent or organic solvent was involved in the process of heparin grafting onto PEEK. The BMP-2 loaded, heparin-grafted PEEK could serve as a potential platform for osseointegration improvement of PEEK-based bone implants. English Royal Society of Chemistry Chemically heparinized PEEK via a green method to immobilize bone morphogenetic protein-2 (BMP-2) for enhanced osteogenic activity Article 10.1039/d3ra07660a 1 RSC Advances, v.14, no.3, pp.1866 - 1874 RSC Advances 14 3 1866 1874 Y scie scopus 001137500400001 2-s2.0-85181765543 Chemistry, Multidisciplinary Chemistry Article SULFONATED POLYETHERETHERKETONE OSTEOBLAST DIFFERENTIATION TITANIUM SURFACES IN-VITRO IMPLANTS DELIVERY GROWTH HYDROGEL INTERFACE MG-63