Kim, Tae-Young Lee, Bum Soo Jo, Beom-Geun Heo, Seong Pil Keem, Min-Ji Kwon, Taek-Hwan Kim, Su-Nam Kim, Ki Hyun Yang, Min Hye 2024-01-19T08:01:54Z 2024-01-19T08:01:54Z 2024-01-18 2023-12 2223-7747 https://pubs.kist.re.kr/handle/201004/112994 Nymphoides peltata (Menyanthaceae) has been used as a medicinal herb in traditional medicines to treat conditions such as strangury, polyuria, swelling, and as a diuretic and antipyretic. In our ongoing research to discover novel structural and/or biological natural products in natural resources, five flavonoids, quercetin (1), quercitrin (2), isoquercetin (3), quercetin-3-O-vicianoside (4), and rutin (5), as well as a new flavonoid glycoside, 3"'-O-foliamenthoyl-rutin (6), were isolated from the MeOH extract of N. peltata roots. The chemical structure of the new compound (6) was determined by analyzing 1D and 2D NMR spectra and high-resolution (HR) electrospray ionization mass spectroscopy (ESIMS), along with a chemical reaction. The wound-healing activities of the isolated compounds (1-6) were evaluated using a HaCaT cell scratch test. Among the isolates, isoquercetin (3), quercetin-3-O-vicianoside (4), and 3"'-O-foliamenthoyl-rutin (6) promoted HaCaT cell migration over scratch wounds, with compound 4 being the most effective. Our findings provide experimental data supporting the potential of quercetin-3-O-vicianoside (4) as a wound-healing agent. English MDPI AG 3'''-O-Foliamenthoyl-Rutin, a New Flavonoid Glycoside from the Roots of Nymphoides peltata Article 10.3390/plants12244083 1 Plants, v.12, no.24 Plants 12 24 Y scie scopus 001132681400001 2-s2.0-85180438078 Plant Sciences Plant Sciences Article AQUATIC PLANT LEAF Salix chaenomeloides phenolic glycoside chaenomelin Helicobacter pylori