Ko, Jihoon Song, Jiyoung Choi, Nakwon Kim, Hong Nam 2024-01-19T08:04:09Z 2024-01-19T08:04:09Z 2023-12-28 2024-03 2192-2640 https://pubs.kist.re.kr/handle/201004/113082 Patient-derived microphysiological systems (P-MPS) have emerged as powerful tools in precision medicine that provide valuable insight into individual patient characteristics. This review discusses the development of P-MPS as an integration of patient-derived samples, including patient-derived cells, organoids, and induced pluripotent stem cells, into well-defined MPSs. Emphasizing the necessity of P-MPS development, its significance as a nonclinical assessment approach that bridges the gap between traditional in vitro models and clinical outcomes is highlighted. Additionally, guidance is provided for engineering approaches to develop microfluidic devices and high-content analysis for P-MPSs, enabling high biological relevance and high-throughput experimentation. The practical implications of the P-MPS are further examined by exploring the clinically relevant outcomes obtained from various types of patient-derived samples. The construction and analysis of these diverse samples within the P-MPS have resulted in physiologically relevant data, paving the way for the development of personalized treatment strategies. This study describes the significance of the P-MPS in precision medicine, as well as its unique capacity to offer valuable insights into individual patient characteristics. Microphysiological systems now integrate patient-derived samples, functioning as physiologically relevant avatars for high-throughput assays. This evolution addresses an unmet clinical need for a patient-centered nonclinical assessment platform, steering toward more precise and personalized approaches in medical research and drug development.image English Wiley-Blackwell Patient-Derived Microphysiological Systems for Precision Medicine Article 10.1002/adhm.202303161 1 Advanced Healthcare Materials, v.13, no.7 Advanced Healthcare Materials 13 7 Y scie scopus 001118467900001 2-s2.0-85179359261 Engineering, Biomedical Nanoscience & Nanotechnology Materials Science, Biomaterials Engineering Science & Technology - Other Topics Materials Science Review ON-A-CHIP PLURIPOTENT STEM-CELLS CIRCULATING TUMOR-CELLS LUNG-CANCER ORGANOIDS MICROFLUIDIC DEVICES BREAST-CANCER AUTOIMMUNE-DISEASES PANCREATIC-CANCER ENDOTHELIAL-CELLS THERAPY RESPONSE microphysiological system patient-derived physiologically-relevant precision medicine