Kumar, Panangattukara Prabhakaran Praveen Kaushal, Shimayali Lim, Dong-Kwon 2024-01-19T08:30:11Z 2024-01-19T08:30:11Z 2023-11-17 2023-11 0165-9936 https://pubs.kist.re.kr/handle/201004/113120 Surface-enhanced Raman scattering (SERS) can be a valuable analytical tool for bioanalysis. However, SERS is a complex optical phenomenon resulting from light-matter interaction. The SERS intensity and spectral feature strongly rely on the status of target molecules on the surface and structure of plasmonic nanomaterials. Among many prerequisites of SERS for practical applications, this review focuses on the fabrication method for sub-10 nm nanogap structures, the method for actively capturing strategies, and the method for data analysis. The recent advance of two different fabrication strategies with plasmonic nanostructures such as top-down and bottom-up have mainly been introduced and compared the advantages and disadvantages of each method, including basic principles. The capturing strategies for specific target analytes are discussed. There has been a significant challenge in data analysis of SERS spectra, because of the complexity of Raman spectrum and fluctuating Raman response. In this regard, recent developments in data science have resulted in the advancement of analytical technology. Beyond typical chemometrics, emerging technologies employing artificial intelligence have shown remarkable progress for practical SERS-based applications. In this review, we focus on the recent advances in the strategies for sensitive and reproducible SERS and the method for post-data processing. English Elsevier BV Recent advances in nano/microfabricated substrate platforms and artificial intelligence for practical surface-enhanced Raman scattering-based bioanalysis Article 10.1016/j.trac.2023.117341 1 TrAC Trends in Analytical Chemistry, v.168 TrAC Trends in Analytical Chemistry 168 N scie scopus 001088689000001 2-s2.0-85173183603 Chemistry, Analytical Chemistry Review SINGLE-MOLECULE PLASMONIC NANOPARTICLES OPTICAL TWEEZERS RECENT PROGRESS HOT-SPOTS SERS SPECTROSCOPY ASSEMBLIES FABRICATION NANOGAP Bioanalytical applications Artificial intelligence Raman scattering Surface-enhanced Raman spectroscopy Top-down method Bottom-up method