Oh, Seyong Yoo, Jae-Young Maeng, Woo-Youl Yoo, Seonggwang Yang, Tianyu Slattery, Susan M. Pessano, Sara Chang, Emily Jeong, Hyoyoung Kim, Jihye Ahn, Hak-Young Kim, Yeongdo Kim, Joohee Xu, Shuai Weese-Mayer, Debra E. Rogers, John A. 2024-01-19T08:32:13Z 2024-01-19T08:32:13Z 2023-09-21 2023-10 0956-5663 https://pubs.kist.re.kr/handle/201004/113215 Temperature is the most commonly collected vital sign in all of clinical medicine; it plays a critical role in care decisions related to topics ranging from infection to inflammation, sleep, and fertility. Most assessments of body temperature occur at isolated anatomical locations (e.g. axilla, rectum, temporal artery, or oral cavity). Even this relatively primitive mode for monitoring can be challenging with vulnerable patient populations due to physical encumbrances and artifacts associated with the sizes, weights, shapes and mechanical properties of the sensors and, for continuous monitoring, their hard-wired interfaces to data collection units. Here, we introduce a simple, miniaturized, lightweight sensor as a wireless alternative, designed to address demanding applications such as those related to the care of neonates in high ambient humidity environments with radiant heating found in incubators in intensive care units. Such devices can be deployed onto specific anatomical locations of premature infants for homeostatic assessments. The estimated core body temperature aligns, to within 0.05 degrees C, with clinical grade, wired sensors, consistent with regulatory medical device requirements. Time-synchronized, multi-device operation across multiple body locations supports continuous, full-body measurements of spatio-temporal variations in temperature and additional modes of determining tissue health status in the context of sepsis detection and various environmental exposures. In addition to thermal sensing, these same devices support measurements of a range of other essential vital signs derived from thermo-mechanical coupling to the skin, for applications ranging from neonatal and infant care to sleep medicine and even pulmonary medicine. English Pergamon Press Ltd. Simple, miniaturized biosensors for wireless mapping of thermoregulatory responses Article 10.1016/j.bios.2023.115545 1 Biosensors and Bioelectronics, v.237 Biosensors and Bioelectronics 237 N scie scopus 001058940700001 2-s2.0-85166317758 Biophysics Biotechnology & Applied Microbiology Chemistry, Analytical Electrochemistry Nanoscience & Nanotechnology Biophysics Biotechnology & Applied Microbiology Chemistry Electrochemistry Science & Technology - Other Topics Article NEONATAL SEPSIS TEMPERATURE BIRTH STABILIZATION BIOMARKERS DIAGNOSIS CORE SKIN MEN Bioelectronics Wireless sensors Thermoregulatory responses Health monitoring