Kang, Wonok Lee, Jinseung Choi, Wonsuk Kim, Jinseok Kim, Junesun Park, Sung-Min 2024-01-19T08:33:37Z 2024-01-19T08:33:37Z 2023-10-29 2023-09 1534-4320 https://pubs.kist.re.kr/handle/201004/113285 Spinal cord stimulation (SCS) is an emerging therapeutic option for patients with neuropathic pain due to spinal cord injury (SCI). Numerous studies on pain relief effects with SCS have been conducted and demonstrated promising results while the mechanisms of analgesic effect during SCS remain unclear. However, an experimental system that enables large-scale long-term animal studies is still an unmet need for those mechanistic studies. This study proposed a fully wireless neurostimulation system that can efficiently support a long-term animal study for neuropathic pain relief. The developed system consists of an implantable stimulator, an animal cage with an external charging coil, and a wireless communication interface. The proposed device has the feature of remotely controlling stimulation parameters via radio-frequency (RF) communication and wirelessly charging via magnetic induction in freely moving rats. Users can program stimulation parameters such as pulse width, intensity, and duration through an interface on a computer. The stimulator was packaged with biocompatible epoxy to ensure long-term durability under in vivo conditions. Animal experiments using SCI rats were conducted to demonstrate the functionality of the device, including long-term usability and therapeutic effects. The developed system can be tailored to individual user needs with commercially available components, thus providing a cost-effective solution for large-scale long-term animal studies on neuropathic pain relief. English Institute of Electrical and Electronics Engineers Fully Implantable Neurostimulation System for Long-Term Behavioral Animal Study Article 10.1109/TNSRE.2023.3315371 1 IEEE Transactions on Neural Systems and Rehabilitation Engineering, v.31, pp.3711 - 3721 IEEE Transactions on Neural Systems and Rehabilitation Engineering 31 3711 3721 Y scie scopus 001071744200002 2-s2.0-85171749535 Engineering, Biomedical Rehabilitation Engineering Rehabilitation Article SPINAL-CORD STIMULATION MECHANICAL HYPERSENSITIVITY ELECTRICAL-STIMULATION NEUROPATHIC PAIN INHIBITION MODEL & nbsp Spinal cord stimulation (SCS) spinal cord injury (SCI) pain relief implantable stimulator survival study