Kim, Hail Choi, Minji Han, Sanghee Park, Sang-Yoon Jeong, Myoungseok Kim, Sang Ryong Hwang, Eun Mi Lee, Seok-Geun 2024-01-19T09:00:36Z 2024-01-19T09:00:36Z 2023-07-27 2023-09 1863-2653 https://pubs.kist.re.kr/handle/201004/113352 Astrocyte elevated gene-1 (AEG-1) is a well-known oncogene implicated in various types of human cancers, including brain tumors. Recently, AEG-1 has also been reported to play pivotal roles in glioma-associated neurodegeneration and neurodegenerative diseases like Parkinson's disease and amyotrophic lateral sclerosis. However, the normal physiological functions and expression patterns of AEG-1 in the brain are not well understood. In this study, we investigated the expression patterns of AEG-1 in the normal mouse brain and found that AEG-1 is widely expressed in neurons and neuronal precursor cells, but little in glial cells. We observed differential expression levels of AEG-1 in various brain regions, and its expression was mainly localized in the cell body of neurons rather than the nucleus. Additionally, AEG-1 was expressed in the cytoplasm of Purkinje cells in both the mouse and human cerebellum, suggesting its potential role in this brain region. These findings suggest that AEG-1 may have important functions in normal brain physiology and warrant further investigation. Our results may also shed light on the differential expression patterns of AEG-1 in normal and pathological brains, providing insights into its roles in various neurological disorders. English Springer Verlag Expression patterns of AEG-1 in the normal brain Article 10.1007/s00429-023-02676-1 1 Brain Structure and Function, v.228, no.7, pp.1629 - 1641 Brain Structure and Function 228 7 1629 1641 N scie scopus 001024238400001 2-s2.0-85164119052 Anatomy & Morphology Neurosciences Anatomy & Morphology Neurosciences & Neurology Article ASTROCYTE-ELEVATED GENE-1 PROTEIN NEURONS PROLIFERATION INTERNEURONS CONTRIBUTES MIGRATION GLUTAMATE PATHWAYS CLONING AEG-1 Normal brain Neurons Glial cells