Lobina, Carla Lee, Jung Hwan Pel, Pisey Chin, Young-Won Kwon, Hak Cheol Colombo, Giancarlo 2024-01-19T09:01:08Z 2024-01-19T09:01:08Z 2022-09-29 2023-09 1478-6419 https://pubs.kist.re.kr/handle/201004/113373 Saikosaponin A (SSA) is the main active ingredient of roots of the East Asian medicinal plant, Bupleurum falcatum L. The present study was aimed at delving into the analgesic properties of SSA in a model of chronic inflammatory pain. To this end, rats were initially treated intraplantarly with complete Freund's adjuvant for induction of hyperalgesia. Twenty-four hours later, rats were acutely treated with SSA (0, 1 and 2 mg/kg, i.p.) and exposed to the Von Frey monofilament test or Randall-Selitto paw pressure test for assessment of mechanical hyperalgesia. Treatment with 2 mg/kg SSA had analgesic effects: the nocifensive reaction (paw withdrawal) occurred later and required application of the nociceptive stimulus at a stronger pressure. The analgesic effects of SSA were of magnitude comparable to that of the effects exerted by the reference compound, acetyl salicylic acid (100 mg/kg, i.p.). The well-described anti-inflammatory properties of SSA likely underlie its analgesic effects. English Taylor & Francis Analgesic effects of saikosaponin A in a rat model of chronic inflammatory pain Article 10.1080/14786419.2022.2124985 1 Natural Product Research, v.37, no.16, pp.2732 - 2736 Natural Product Research 37 16 2732 2736 N scie scopus 000855345300001 Chemistry, Applied Chemistry, Medicinal Chemistry Pharmacology & Pharmacy Article Saikosaponin A Bupleurum falcatum L chronic inflammatory pain complete Freund&apos s adjuvant Von Frey monofilament test Randall-Selitto paw pressure test rat