Jeong, Goeen Han, Hyung-Seop Jeon, Hojeong Kim, Yu-Chan Jang, Ho Won Ok, Myoung-Ryul 2024-01-19T09:05:27Z 2024-01-19T09:05:27Z 2023-01-19 2023-07 1598-9623 https://pubs.kist.re.kr/handle/201004/113571 Biodegradable metals have received limited attention for application in transdermal drug delivery, although metallic microneedles (MNs) and iontophoresis have been thoroughly researched for this purpose. Here, we present Mg as a salient candidate for an MN electrode. Its metallic properties enable the application of voltage to enhance the diffusion of charged drug molecules, while hydrogen gas generated during Mg corrosion prevents its application to electrodes. The Mg MN electrode was fabricated using a nanosecond laser, and the amount of hydrogen gas were measured with applied potential during iontophoresis. Accordingly, an appropriate potential window for iontophoresis was established based on the combined effect of enhanced drug diffusion by applied electric potential and impediment from hydrogen generation. The dye permeation tests of the Mg MN on the porcine skin demonstrated the combined effect of the Mg MN and iontophoresis. The dye migration decreased at higher voltages due to excess hydrogen generation and the corrosion of needle tips, both making the diffusion of charged dye molecules along the Mg MN surface harder. These results demonstrate optimal potential range of Mg MN electrodes for transdermal drug delivery with an electric field and bubble generation during iontophoresis. English 대한금속·재료학회 Biodegradable Mg Electrodes for Iontophoretic Transdermal Drug Delivery Article 10.1007/s12540-022-01345-y 1 Metals and Materials International, v.29, no.7, pp.2084 - 2092 Metals and Materials International 29 7 2084 2092 Y scie scopus kci ART002975660 000905397800001 2-s2.0-85145078896 Materials Science, Multidisciplinary Metallurgy & Metallurgical Engineering Materials Science Metallurgy & Metallurgical Engineering Article MICRONEEDLE ARRAYS CORROSION SKIN FORMULATIONS COMBINATION FABRICATION DEVICES Magnesium Microneedle Iontophoresis Transdermal drug delivery