El-Damasy, Ashraf K. Jin, Heewon Sabry, Mohamed A. Kim, Hyun Ji Alanazi, Mohammed M. Seo, Seon Hee Bang, Eun-Kyoung Keum, Gyochang 2024-01-19T09:30:39Z 2024-01-19T09:30:39Z 2023-07-20 2023-06 1010-660X https://pubs.kist.re.kr/handle/201004/113637 A new series of 3,4,5-trimethoxyphenyl thiazole pyrimidines has been synthesized and biologically evaluated for its in vitro anticancer activity. Compounds 4a, 4b, and 4h with substituted piperazine showed the best antiproliferative activity. In the NCI-60 cell line screening, compound 4b showed promising cytostatic activity against multiple cell lines. Notably, it elicited a GI value of 86.28% against the NSCL cancer cell line HOP-92 at a 10 & mu;M dose. Compounds 4a and 4h at 10 & mu;M showed promising GI values of 40.87% and 46.14% against HCT-116 colorectal carcinoma and SK-BR-3 breast cancer cell lines, respectively. ADME-Tox prediction of compounds 4a, 4b, and 4h revealed their acceptable drug-likeness properties. In addition, compounds 4a, 4b, and 4h showed a high probability of targeting kinase receptors via Molinspiration and Swiss TargetPrediction. English MDPI Design and Synthesis of New 4-(3,4,5-Trimethoxyphenyl)Thiazole-Pyrimidine Derivatives as Potential Antiproliferative Agents Article 10.3390/medicina59061076 1 Medicina (Kaunas, Lithuania), v.59, no.6 Medicina (Kaunas, Lithuania) 59 6 Y scie scopus 001017150600001 2-s2.0-85163747478 Medicine, General & Internal General & Internal Medicine Article TYROSINE KINASE INHIBITOR BIOLOGICAL EVALUATION CANCER DASATINIB trimethoxyphenyl thiazole pyrimidines NCI-60 screening NSCL cancer cell line ADME-Tox prediction