Sang, Mingyu Cho, Myeongki Lim, Selin Min, In Sik Han, Yuna Lee, Chanwoo Shin, Jongwoon Yoon, Kukro Yeo, Woon-Hong Lee, Taeyoon Won, Sang Min Jung, Youngmee Heo, Yun Jung Yu, Ki Jun 2024-01-19T09:30:40Z 2024-01-19T09:30:40Z 2023-07-20 2023-06 https://pubs.kist.re.kr/handle/201004/113638 Continuous glucose monitoring (CGM) allows patients with diabetes to manage critical disease effectively and autonomously and prevent exacerbation. A painless, wireless, compact, and minimally invasive device that can provide CGM is essential for monitoring the health conditions of freely moving patients with diabetes. Here, we propose a glucose-responsive fluorescence-based highly sensitive biodegradable microneedle CGM system. These ultrathin and ultralight microneedle sensor arrays continuously and precisely monitored glucose concen-tration in the interstitial fluid with minimally invasive, pain-free, wound-free, and skin inflammation-free out-comes at various locations and thicknesses of the skin. Bioresorbability in the body without a need for device removal after use was a key characteristic of the microneedle glucose sensor. We demonstrated the potential long-term use of the bioresorbable device by applying the tether-free CGM system, thus confirming the success-ful detection of glucose levels based on changes in fluorescence intensity. In addition, this microneedle glucose sensor with a user-friendly designed home diagnosis system using mobile applications and portable accessories offers an advance in CGM and its applicability to other bioresorbable, wearable, and implantable monitoring device technology. English American Association for the Advancement of Science Fluorescent-based biodegradable microneedle sensor array for tether-free continuous glucose monitoring with smartphone application Article 10.1126/sciadv.adh1765 1 Science Advances, v.9, no.22 Science Advances 9 22 Y scie scopus 001009737900021 2-s2.0-85160751720 Multidisciplinary Sciences Science & Technology - Other Topics Article DIABETES-MELLITUS PENETRATION FABRICATION RELEASE MICE SOFT