Lee, Rami Kim, Ji-Hun Hwang, Hongik Rhim, Hyewhon Hwang, Sung-Hee Cho, Ik-Hyun Kim, Do-Geun Kim, Hyoung-Chun Nah, Seung-Yeol 2024-01-19T09:31:05Z 2024-01-19T09:31:05Z 2023-06-29 2023-06 2072-6643 https://pubs.kist.re.kr/handle/201004/113659 Ginseng is one of the traditional herbal medicines for tonic. Gintonin is a new material derived from white/red ginseng and its lysophosphatidic acids (LPAs) play as a ligand for G protein-coupled LPA receptors. Korean red ginseng marc (KRGM) is a by-product after the KRG processes. We developed a low-cost/high-efficiency method for KRGM gintonin production. We further studied the KRGM gintonin-mediated anti-skin aging effects under UVB exposure using human dermal fibroblasts (HDFs). KRGM gintonin yield is about 8%. KRGM gintonin contains a high amount of LPA C18:2, lysophosphatidylcholine (LPC), and phosphatidylcholine (PC), which is similar to white ginseng gintonin. KRGM gintonin induced [Ca2+](i) transient via LPA1/3 receptors and increased cell viability/proliferation under UVB exposure. The underlying mechanisms of these results are associated with the antioxidant action of KRGM gintonin. KRGM gintonin attenuated UVB-induced cell senescence by inhibiting cellular beta-galactosidase overexpression and facilitated wound healing. These results indicate that KRGM can be a novel bioresource of KRGM gintonin, which can be industrially utilized as new material for skin nutrition and/or skin healthcare. English Multidisciplinary Digital Publishing Institute (MDPI) Preparation of Red Ginseng Marc-Derived Gintonin and Its Application as a Skin Nutrient Article 10.3390/nu15112574 1 Nutrients, v.15, no.11 Nutrients 15 11 Y scie scopus 001003602400001 2-s2.0-85161376684 Nutrition & Dietetics Nutrition & Dietetics Article PHYSICOCHEMICAL PROPERTIES DIETARY SUPPLEMENTATION WHITE PERFORMANCE Korean red ginseng marc gintonin LPA receptors skin damage cosmetics