Winarto, Jessica Song, Dae-Geun Pan, Cheol-Ho 2024-01-19T09:32:35Z 2024-01-19T09:32:35Z 2023-06-29 2023-05 1661-6596 https://pubs.kist.re.kr/handle/201004/113735 Chronic liver disease (CLD) has emerged as a leading cause of human deaths. It caused 1.32 million deaths in 2017, which affected men more than women by a two-to-one ratio. There are various causes of CLD, including obesity, excessive alcohol consumption, and viral infection. Among them, non-alcoholic fatty liver disease (NAFLD), one of obesity-induced liver diseases, is the major cause, representing the cause of more than 50% of cases. Fucoxanthin, a carotenoid mainly found in brown seaweed, exhibits various biological activities against NAFLD. Its role in NAFLD appears in several mechanisms, such as inducing thermogenesis in mitochondrial homeostasis, altering lipid metabolism, and promoting anti-inflammatory and anti-oxidant activities. The corresponding altered signaling pathways are the beta 3-adorenarine receptor (beta 3Ad), proliferator-activated receptor gamma coactivator (PGC-1), adenosine monophosphate-activated protein kinase (AMPK), peroxisome proliferator-activated receptor (PPAR), sterol regulatory element binding protein (SREBP), nuclear factor kappa B (NF-kappa B), mitogen-activated protein kinase (MAPK), protein kinase B (AKT), SMAD2/3, and P13K/Akt pathways. Fucoxanthin also exhibits anti-fibrogenic activity that prevents non-alcoholic steatohepatitis (NASH) development. English Multidisciplinary Digital Publishing Institute (MDPI) The Role of Fucoxanthin in Non-Alcoholic Fatty Liver Disease Article 10.3390/ijms24098203 1 International Journal of Molecular Sciences, v.24, no.9 International Journal of Molecular Sciences 24 9 Y scie scopus 000987517800001 2-s2.0-85159266647 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Review DIET-INDUCED OBESITY BROWN ADIPOSE-TISSUE OXIDATIVE STRESS CAROTENOID FUCOXANTHIN MITOCHONDRIAL PROTON LIPID-ACCUMULATION HEPATIC STEATOSIS SINGLET OXYGEN HEPG2 CELLS MICE liver non-alcoholic obesity thermogenesis fucoxanthin lipid fibrosis