Kim, Juyong Seo, Sangwoo Park, Jung Han Yoon Lee, Ki Won Kim, Jiyoung Kim, Jin-Chul 2024-01-19T09:32:47Z 2024-01-19T09:32:47Z 2023-06-15 2023-05 1016-8478 https://pubs.kist.re.kr/handle/201004/113744 Transient receptor potential vanilloid 1 (TRPV1) protein is a Ca2+-permeable non-selective cation channel known for its pain modulation pathway. In a previous study, it was discovered that a triple-transgenic Alzheimer's disease (AD) mouse model (3xTg-AD+/+) has anti-AD effects. The expression of proteins in the brain-derived neurotrophic factor (BDNF)/cAMP response element binding protein (CREB) pathway in a 3xTg-AD/TRPV1 transgenic mice model was investigated to better understand the AD regulatory effect of TRPV1 deficiency. The results show that TRPV1 deficiency leads to CREB activation by increasing BDNF levels and promoting phosphorylation of tyrosine receptor kinase B (TrkB), extracellular signal-regulated kinase (ERK), protein kinase B (Akt), and CREB in the hippocampus. Additionally, TRPV1 deficiency-induced CREB activation increases the antiapoptotic factor B-cell lymphoma 2 (Bcl-2) gene, which consequently downregulates Bcl-2-associated X (Bax) expression and decreases cleaved caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP), which leads to the prevention of hippocampal apoptosis. In conclusion, TRPV1 deficiency exhibits neuroprotective effects by preventing apoptosis through the BDNF/CREB signal transduction pathway in the hippocampus of 3xTg-AD mice. English 한국분자세포생물학회 Ca2+-Permeable TRPV1 Receptor Mediates Neuroprotective Effects in a Mouse Model of Alzheimer's Disease via BDNF/CREB Signaling Pathway Article 10.14348/molcells.2023.2156 1 Molecules and Cells, v.46, no.5, pp.319 - 328 Molecules and Cells 46 5 319 328 Y scie scopus kci ART002967238 000996386200002 2-s2.0-85159741256 Biochemistry & Molecular Biology Cell Biology Biochemistry & Molecular Biology Cell Biology Article CASPASE-3 ACTIVATION SYNAPTIC PLASTICITY NMDA RECEPTORS EXPANDING ROLE AMYLOID-BETA APOPTOSIS MEMANTINE BDNF CALCIUM BCL-2 brain-derived neurotrophic factor cAMP response element binding protein transient receptor potential vanilloid 1 Alzheimer&apos s disease apoptosis