Lee, Joong Hoon Jang, Tae-Min Shin, Jeong-Woong Lim, Bong Hee Rajaram, Kaveti Han, Won Bae Ko, Gwan-Jin Yang, Seung Min Han, Sungkeun Kim, Dong-Je Kang, Heeseok Lim, Jun Hyeon Lee, Kyu-Sung Park, Eunkyoung Hwang, Suk-Won 2024-01-19T09:33:14Z 2024-01-19T09:33:14Z 2023-05-11 2023-05 1936-0851 https://pubs.kist.re.kr/handle/201004/113767 Current standard clinical options for patients with detrusor underactivity (DUA) or underactive bladder-the inability to release urine naturally-include the use of medications, voiding techniques, and intermittent catheterization, for which the patient inserts a tube directly into the urethra to eliminate urine. Although those are life-saving techniques, there are still unfavorable side effects, including urinary tract infection (UTI), urethritis, irritation, and discomfort. Here, we report a wireless, fully implantable, and expandable electronic complex that enables elaborate management of abnormal bladder function via seamless integrations with the urinary bladder. Such electronics can not only record multiple physiological parameters simultaneously but also provide direct electrical stimulation based on a feedback control system. Uniform distribution of multiple stimulation electrodes via mesh-type geometry realizes low-impedance characteristics, which improves voiding/urination efficiency at the desired times. In vivo evaluations using live, free-moving animal models demonstrate system-level functionality. English American Chemical Society Wireless, Fully Implantable and Expandable Electronic System for Bidirectional Electrical Neuromodulation of the Urinary Bladder Article 10.1021/acsnano.3c00755 1 ACS Nano, v.17, no.9, pp.8511 - 8520 ACS Nano 17 9 8511 8520 N scie scopus 000974400900001 2-s2.0-85154533244 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Article TRACT DYSFUNCTION STIMULATION MODEL expandable electronics fully implantable platform wireless electrical stimulation biomedical devices urinary bladder underactive bladder