Kudaibergen, Dauletkerey Park, Hyun Su Park, Jinwook Im, Gwang-Bum Lee, Ju-Ro Joung, Yoon Ki Bhang, Suk Ho Kim, Jae-Hyuk 2024-01-19T10:00:32Z 2024-01-19T10:00:32Z 2023-02-23 2023-04 1738-2696 https://pubs.kist.re.kr/handle/201004/113886 Recently, various attempts have been made to apply diverse types of nanoparticles in biotechnology. Silica nanoparticles (SNPs) have been highlighted and studied for their selective accumulation in diseased parts, strong physical and chemical stability, and low cytotoxicity. SNPs, in particular, are very suitable for use in drug delivery and bioimaging, and have been sought as a treatment for ischemic diseases. In addition, mesoporous silica nanoparticles have been confirmed to efficiently deliver various types of drugs owing to their porous structure. Moreover, there have been innovative attempts to treat ischemic diseases using SNPs, which utilize the effects of Si ions on cells to improve cell viability, migration enhancement, and phenotype modulation. Recently, external stimulus-responsive treatments that control the movement of magnetic SNPs using external magnetic fields have been studied. This review addresses several original attempts to treat ischemic diseases using SNPs, including particle synthesis methods, and presents perspectives on future research directions. English 한국조직공학과 재생의학회 Silica-Based Advanced Nanoparticles For Treating Ischemic Disease Article 10.1007/s13770-022-00510-z 1 Tissue Engineering and Regenerative Medicine, v.20, no.2, pp.177 - 198 Tissue Engineering and Regenerative Medicine 20 2 177 198 N scie scopus kci ART002946947 000921640800001 2-s2.0-85146702893 Cell & Tissue Engineering Engineering, Biomedical Cell Biology Engineering Review DRUG-DELIVERY MAGNETIC NANOPARTICLES HYDROGEN-SULFIDE PROGENITOR CELLS TISSUE SYSTEM PROLIFERATION OSTEOGENESIS CYTOTOXICITY ANGIOGENESIS Silica nanoparticle Silica based magnetic nanoparticle Ischemic disease treatment Drug delivery system Bioimaging