Lee, Jangwook Kim, Kwangmeyung Kwon, Ick Chan Lee, Kuen Yong 2024-01-19T10:02:27Z 2024-01-19T10:02:27Z 2023-02-17 2023-03 0935-9648 https://pubs.kist.re.kr/handle/201004/113961 A new anticancer strategy to exploit abnormal metabolism of cancer cells rather than to merely control the drug release or rearrange the tumor microenvironment is reported. An antiglycolytic amphiphilic polymer, designed considering the unique metabolism of cancer cells (Warburg effect) and aimed at the regulation of glucose metabolism, is synthesized through chemical conjugation between glycol chitosan (GC) and phenylboronic acid (PBA). GC-PBA derivatives form stable micellar structures under physiological conditions and respond to changes in glucose concentration. Once the micelles accumulate at the tumor site, intracellular glucose capture occurs, and the resultant energy deprivation through the inhibition of aerobic glycolysis remarkably suppresses tumor growth without significant side effects in vivo. This strategy highlights the need to develop safe and effective cancer treatment without the use of conventional anticancer drugs. English WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Intracellular Glucose-Depriving Polymer Micelles for Antiglycolytic Cancer Treatment Article 10.1002/adma.202207342 1 Advanced Materials, v.35, no.10 Advanced Materials 35 10 N scie scopus 000920571300001 2-s2.0-85147290721 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article; Early Access DELIVERY METABOLISM THERAPY MICROENVIRONMENT apoptosis cancer therapy glucose-responsive polymers induced energy deficiency nutrient deprivation