Baskar Selvaraj Lee, Sang Hyuk Nguyen Qui Sang Ngoc Lee, Heesu Lee, Jae Wook 2024-01-19T10:02:52Z 2024-01-19T10:02:52Z 2023-01-26 2023-03 0253-2964 https://pubs.kist.re.kr/handle/201004/113979 Twenty novel cardamonin derivatives were synthesized and evaluated for antiproliferative activity against four cancer cell lines (HT-29, DLD-1, MDA-MB-231, and HepG2). Among the derivatives, SWA2 showed the most potent effects with an IC50 value of 4.43-11.0 mu M against three cancer cell lines except for HepG2. Further investigation showed that SWA2 induced cancer cell death by apoptosis. Flow cytometry analysis showed that SWA2 treatment increased the ratio of apoptotic and dead cells. Further western blot analysis revealed that SWA2 treatment increased cleaved PARP. In summary, SWA2 can be utilized as a lead structure for anticancer therapy. English 대한화학회 Synthesis and evaluation of cardamonin derivatives as antiproliferative agents to human cancer cells Article 10.1002/bkcs.12658 1 Bulletin of the Korean Chemical Society, v.44, no.3, pp.208 - 212 Bulletin of the Korean Chemical Society 44 3 208 212 N scie scopus kci ART002939646 000910671700001 2-s2.0-85146191578 Chemistry, Multidisciplinary Chemistry Article; Early Access DOWN-REGULATION INHIBITION anticancer cardamonin derivatives chalcone