Yoon, Goo Shim, Jung-Hyun Kim, Hyun Jung Kim, Su-Nam Bae, Min-Suk Cho, Seung-Sik Kim, Eunae 2024-01-19T10:03:01Z 2024-01-19T10:03:01Z 2023-01-03 2023-03 0253-2964 https://pubs.kist.re.kr/handle/201004/113984 High-performance liquid chromatography analysis of the ethyl acetate fraction of Paeonia lactiflora roots led to the detection of five compounds: gallic acid (GA) (1), methyl gallate (2), albiflorin (4), paeoniflorin (5), and pentagalloylglucose (6). Among them, pentagalloylglucose (6) showed cytotoxicity against human breast cancer cells MCF-7 and MDA-MB-231 in vitro with IC50 values of 20.1 and 14.4 mu M, respectively. Through the structure-activity relationship of GA, which is an important backbone of pentagalloylglucose, we found that its three hydroxy groups were important for its cytotoxicity, and that the 3-O-methylgallic acid structure was only effective against a triple-negative breast cancer cell line. Furthermore, drug efficacy was confirmed by increasing its lipid affinity through the synthesis of various ester derivatives of gallic acid. English 대한화학회 Structure-activity relationship of gallic acid from Paeonia lactiflora and its synthetic analogs against human breast cancer cells Article 10.1002/bkcs.12657 1 Bulletin of the Korean Chemical Society, v.44, no.3, pp.222 - 229 Bulletin of the Korean Chemical Society 44 3 222 229 N scie scopus kci ART002939651 000895080200001 2-s2.0-85144044899 Chemistry, Multidisciplinary Chemistry Article ESTERS PENTAGALLOYLGLUCOSE DERIVATIVES MCF-7 triple-negative breast cancer 3-O-methylgallic acid breast cancer gallic acid Paeonia lactiflora roots pentagalloylglucose