Song, Joseph W. Ryu, Hanjun Bai, Wubin Xie, Zhaoqian Vazquez-Guardado, Abraham Nandoliya, Khizar Avila, Raudel Lee, Geumbee Song, Zhen Kim, Jihye Lee, Min-Kyu Liu, Yugang Kim, Mirae Wang, Huifeng Wu, Yixin Yoon, Hong-Joon Kwak, Sung Soo Shin, Jaeho Kwon, Kyeongha Lu, Wei Chen, Xuexian Huang, Yonggang Ameer, Guillermo A. Rogers, John A. 2024-01-19T10:03:21Z 2024-01-19T10:03:21Z 2023-11-15 2023-02 https://pubs.kist.re.kr/handle/201004/113993 Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy. English American Association for the Advancement of Science Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites Article 10.1126/sciadv.ade4687 1 Science Advances, v.9, no.8 Science Advances 9 8 Y scie scopus 000949019100019 2-s2.0-85148551109 Multidisciplinary Sciences Science & Technology - Other Topics Article DIABETIC FOOT ULCERS ELECTRICAL-STIMULATION TISSUE SKIN HEAT