Cui, Jinsheng Ye, Suhyun Shin, Daniel Cho, Illhwan Kim, Hye Yun Kwon, Yun Park, Keunwan Nam, Sang-Jip Kim, YoungSoo Oh, Dong-Chan 2024-01-19T10:03:45Z 2024-01-19T10:03:45Z 2023-03-16 2023-02 1660-3397 https://pubs.kist.re.kr/handle/201004/114014 Two new glycosylated and succinylated macrocyclic lactones, succinyl glyco-oxydifficidin (1) and succinyl macrolactin O (2), were isolated from a Bacillus strain collected from an intertidal mudflat on Anmyeon Island in Korea. The planar structures of 1 and 2 were proposed using mass spectrometric analysis and NMR spectroscopic data. The absolute configurations of 1 and 2 were determined by optical rotation, J-based configuration analysis, chemical derivatizations, including the modified Mosher's method, and quantum-mechanics-based calculation. Biological evaluation of 1 and 2 revealed that succinyl glyco-oxydifficidin (1) inhibited/dissociated amyloid beta (A beta) aggregation, whereas succinyl macrolactin O (2) inhibited A beta aggregation, indicating their therapeutic potential for disassembling and removing A beta aggregation. English Multidisciplinary Digital Publishing Institute (MDPI) Glycosylated and Succinylated Macrocyclic Lactones with Amyloid-beta-Aggregation-Regulating Activity from a Marine Bacillus sp. Article 10.3390/md21020067 1 Marine Drugs, v.21, no.2 Marine Drugs 21 2 Y scie scopus 000941637300001 2-s2.0-85148884854 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article DRUG DISCOVERY STEREOCHEMISTRY MACROLACTINS INHIBITORS BACTERIUM glycosylation succinylation macrocyclic lactone absolute configuration Bacillus sp amyloid-beta