Maccioni, Paola Chin, Young-Won Corelli, Federico Kwon, Hak Cheol Colombo, Giancarlo 2024-01-19T10:04:06Z 2024-01-19T10:04:06Z 2023-03-02 2023-02 1478-6419 https://pubs.kist.re.kr/handle/201004/114032 Saikosaponin A (SSA) is an active ingredient of the Asian medicinal herb, Bupleurum falcatum L. When administered via the intraperitoneal (i.p.) route, SSA suppressed multiple addictive-like behaviours, including operant alcohol self-administration, in rodents. It is unknown whether these effects are retained after intragastric (i.g.) administration, a desirable prerequisite for a compound with therapeutic potential. To fill this gap, i.g. SSA (0, 50, and 100 mg/kg) was tested in Sardinian alcohol-preferring (sP) rats trained to lever-respond for oral alcohol. SSA reduced lever-responding and amount of self-administered alcohol. However, when compared to i.p. SSA, i.g. SSA resulted to be markedly less potent and effective, suggestive of reduced bioavailability after i.g. treatment. Finally, and in agreement with previous data on the suppressing effect of i.p. SSA on behaviours motivated by highly palatable foods, i.g. SSA (0, 50, and 100 mg/kg) reduced oral sucrose self-administration in a separate set of sP rats. English Taylor & Francis Reducing effect of intragastrically administered saikosaponin A on alcohol and sucrose self-administration in rats Article 10.1080/14786419.2023.2177848 1 Natural Product Research, v.37, no.24, pp.4256 - 4260 Natural Product Research 37 24 4256 4260 N scie scopus 000932251300001 2-s2.0-85147985640 Chemistry, Applied Chemistry, Medicinal Chemistry Pharmacology & Pharmacy Article BUPLEURUM-FALCATUM ACTIVE INGREDIENT Saikosaponin A Bupleurum falcatum L intragastric route of administration operant alcohol self-administration operant sucrose self-administration Sardinian alcohol-preferring rats