Lee, Taeju Park, Jee-Ho Cha, Ji-Hyoung Chou, Namsun Je, Minkyu Kim, Ji-Hoon Cho, Il-Joo Kim, Seong-Jin Jang, Doojin 2024-01-19T10:08:21Z 2024-01-19T10:08:21Z 2022-02-28 2019-06 https://pubs.kist.re.kr/handle/201004/114084 This paper presents a multimodal multichannel neural activity readout IC which can perform not only the electrical recording (ER) but also the fluorescence recording (FR) of neural activity for the cell-type-specific study of heterogeneous neuronal cell populations. The time-based FR circuit senses Ca2+ concentration using Ca(2+)probes while the ER circuit acquires action potentials (APs) and local field potentials (LFPs). The IC is fabricated in 0.18 mu m CMOS, The FR circuit achieves a recording range of 81dB (75pA to 860nA) and consumes the power of 0.7 mu W/Ch. The ER circuit achieves the input-referred noise (IRN) of 2.7 mu V-rms over the bandwidth (BW) of 10kHz, while consuming the power of 4.9 mu W/Ch. The in-vitro measurement is performed for recording Ca2+ concentration and electrical neural signals. English IEEE A Multimodal Multichannel Neural Activity Readout IC with 0.7 mu W/Channel Ca2+-Probe-Based Fluorescence Recording and Electrical Recording Conference 1 Symposium on VLSI Technology / 33rd Symposium on VLSI Circuits, pp.C290 - C291 Symposium on VLSI Technology / 33rd Symposium on VLSI Circuits C290 C291 US Kyoto, JAPAN 2019-06-09 2019 SYMPOSIUM ON VLSI CIRCUITS 000531736500098 2-s2.0-85073899513