Kim, Jae Yeon Kil, Ye Chan Yang, Da Hye Park, Dal Yong Jang, Hee Jun Park, Song-Kyu Jung, Yong Woo Yoon, Hong Yeol Kim, Kwangmeyung Song, Daesub Yuk, Soon Hong 2024-01-19T10:30:24Z 2024-01-19T10:30:24Z 2023-03-10 2023-01 0927-7765 https://pubs.kist.re.kr/handle/201004/114115 Phototherapeutic nanoparticles (NPs) were prepared with methylene blue (MB), indocyanine green (ICG), and Solutol through self-assembly. Generation of reactive oxygen species and elevation of temperature were observed that verify the photodynamic/photothermal effects of the NPs. Morphology and size distribution of the NPs were examined by transmittance electron microscopy and dynamic light scattering. The biodistribution of the NPs and their antitumor efficacy were examined using tumor-bearing mice to understand the phototherapeutic effect of the NPs on tumors. To enhance targetability with enhanced therapeutic efficacy, empty NPs (Solutol nano -particles without MB and ICG) at different concentrations were injected along with the phototherapeutic NPs. Enhanced delivery of the phototherapeutic NPs at the tumor site was examined based on hepatocyte overload. English Elsevier BV Enhanced delivery of the phototherapeutic nanoparticles via hepatocyte overload Article 10.1016/j.colsurfb.2022.112959 1 Colloids and Surfaces B: Biointerfaces, v.221 Colloids and Surfaces B: Biointerfaces 221 N scie scopus 000918494100003 2-s2.0-85141273972 Biophysics Chemistry, Physical Materials Science, Biomaterials Biophysics Chemistry Materials Science Article NIR PHOTOTHERMAL THERAPY GOLD NANOPARTICLES MIXED MICELLES COMBINATION METASTASIS Phototheraputic nanoparticles Methylene blue Indocyanine green Solutol Hepatocyte overload