Park, Subin Kim, Ji-Young Kwon, Hak Cheol Jang, Dae Sik Song, Yoon-Jae 2024-01-19T10:30:50Z 2024-01-19T10:30:50Z 2023-02-03 2023-01 1420-3049 https://pubs.kist.re.kr/handle/201004/114136 Screening of the antiviral and virucidal activities of ethanol extracts from plants endemic to the Republic of Korea revealed the inhibitory activity of a 70% ethanol extract of the whole plant of A. pseudoglehnii (APE) against influenza virus infection. Two chlorophyll derivatives, ethyl pheophorbides a and b, isolated as active components of APE, exerted virucidal effects with no evident cytotoxicity. These compounds were effective only under conditions of direct incubation with the virus, and exerted no effects on the influenza A virus (IAV) surface glycoproteins hemagglutinin (HA) and neuraminidase (NA). Interestingly, virucidal activities of ethyl pheophorbides a and b were observed against enveloped but not non-enveloped viruses, suggesting that these compounds act by affecting the integrity of the viral membrane and reducing infectivity. English Multidisciplinary Digital Publishing Institute (MDPI) Antiviral Activities of Ethyl Pheophorbides a and b Isolated from Aster pseudoglehnii against Influenza Viruses Article 10.3390/molecules28010041 1 Molecules, v.28, no.1 Molecules 28 1 Y scie scopus 000909085500001 2-s2.0-85145700807 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Article RESISTANCE CONSTITUENTS STRATEGIES ACTIVATION EXTRACT Aster pseudoglehnii endemic plants ethyl pheophorbide chlorophyll derivative virucidal