Cho, Eunsil Park, Jinsil Hwang, Eun Mi Kim, Hyung Wook Park, Jae-Yong 2024-01-19T10:31:09Z 2024-01-19T10:31:09Z 2023-01-19 2023-01 1756-6606 https://pubs.kist.re.kr/handle/201004/114152 The 14-3-3 protein family with seven isoforms found in mammals is widely expressed in the brain and plays various roles in cellular processes. Several studies have reported that 14-3-3 gamma, one of the 14-3-3 protein isoforms, is associated with neurological and psychiatric disorders, but the role of 14-3-3 gamma in the pathophysiology of brain diseases is unclear. Although studies have been conducted on the relationship between 14-3-3 gamma protein and Parkinson's disease (PD), a common neurodegenerative disorder with severe motor symptoms such as bradykinesia and rigidity, a direct connection remains to be elucidated. We recently showed that adult heterozygous 14-3-3 gamma knockout mice are hyperactive and exhibit anxiety-like behavior. In this study, we further characterized the molecular and behavioral changes in aged 14-3-3 gamma heterozygous mice to investigate the role of 14-3-3 gamma in the brain. We observed decreased dopamine levels and altered dopamine metabolism in the brains of these mice, including changes in the phosphorylation of proteins implicated in PD pathology. Furthermore, we confirmed that they displayed PD symptom-like behavioral deficits, such as impaired motor coordination and decreased ability to the nest-building activity. These findings suggest an association between 14-3-3 gamma dysfunction and PD pathophysiology. English BioMed Central 14-3-3γ haploinsufficiency leads to altered dopamine pathway and Parkinson’s disease-like motor incoordination in mice Article 10.1186/s13041-022-00990-z 1 Molecular Brain, v.16, no.1 Molecular Brain 16 1 Y scie scopus 000909512200002 2-s2.0-85145645661 Neurosciences Neurosciences & Neurology Article CEREBROSPINAL-FLUID ALZHEIMERS-DISEASE KINASE-ACTIVITY MPTP TOXICITY LEWY BODIES BRAIN PROTEINS LRRK2 ISOFORMS 14-3-3-PROTEINS 14-3-3 gamma Dopamine Motor incoordination Parkinson&apos s disease