Yang, Woojin Seo, Jiwon Kim, Jae Hong 2024-01-19T10:31:15Z 2024-01-19T10:31:15Z 2023-01-13 2023-01 2040-3364 https://pubs.kist.re.kr/handle/201004/114157 Recent outbreaks of both new and existing infectious pathogens have threatened healthcare systems around the world. Therefore, it is vital to detect and neutralize pathogens to prevent their spread and treat infected patients. This consideration has led to the development of biosensors and antibiotics inspired by the structure and function of antibodies and antimicrobial peptides (AMPs), which constitute adaptive and innate immunity, efficiently protecting the human body against invading pathogens. Herein, we provide an overview of recent advances in the detection and neutralization of pathogens using protein-mimetic peptoid nanoarchitectures. Peptoids are bio-inspired and sequence-defined polymers composed of repeating N-substituted glycine units. They can spontaneously fold into well-defined three-dimensional nanostructures that encode chemical information depending on their sequences. Loop-functionalized peptoid nanosheets have been constructed by mimicking antibodies containing chemically variable loops as binding motifs for their respective target pathogen. Furthermore, by mimicking the cationic amphipathic features of natural AMPs, helical peptoids and their assemblies have been developed to achieve selective anti-infective activity owing to their intrinsic ability to interact with bacterial membranes and viral envelopes. We believe that this mini-review furnishes in-depth insight into how to construct protein-like nanostructures via the self-assembly of peptoids for application in the detection of pathogens and the treatment of infectious diseases for future healthcare applications. English Royal Society of Chemistry Protein-mimetic peptoid nanoarchitectures for pathogen recognition and neutralization Article 10.1039/d2nr05326h 1 Nanoscale, v.15, no.3, pp.975 - 986 Nanoscale 15 3 975 986 N scie scopus 000901439500001 2-s2.0-85144808855 Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Chemistry Science & Technology - Other Topics Materials Science Physics Review; Early Access PEPTIDE POLYPEPTOIDS CONFORMATION POLYVALENT NANOSHEETS FAMILY N-SUBSTITUTED GLYCINES AROMATIC SIDE-CHAINS OLIGOMERS