Park, Subin Kim, Na-Eun Park, Bang Ju Kwon, Hak Cheol Song, Yoon-Jae 2024-01-19T10:32:26Z 2024-01-19T10:32:26Z 2023-01-13 2022-12 1424-8247 https://pubs.kist.re.kr/handle/201004/114213 Kaempferol, a natural flavonoid abundantly found in plants, is known to have pharmacological properties, such as anti-inflammatory and anti-cancer effects. In this study, we investigated the antiviral effects of kaempferol against a varicella-zoster virus (VZV) clinical isolate in vitro. We found that kaempferol significantly inhibited VZV replication without exhibiting cytotoxicity. Kaempferol exerted its antiviral effect at a similar stage of the VZV life cycle as acyclovir, which inhibits VZV DNA replication. Taken together, our results suggest that kaempferol inhibits VZV infection by blocking the DNA replication stage in the viral life cycle. English Multidisciplinary Digital Publishing Institute (MDPI) Kaempferol Interferes with Varicella-Zoster Virus Replication in Human Foreskin Fibroblasts Article 10.3390/ph15121582 1 Pharmaceuticals, v.15, no.12 Pharmaceuticals 15 12 Y scie scopus 000904530600001 2-s2.0-85144675481 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article HERPES-SIMPLEX-VIRUS IDENTIFICATION FLAVONOIDS varicella-zoster virus antiviral kaempferol