Yang, Seung Won Jang, Soon Ho Jang, Myoungjin Kim, Ga Hee Kwon, Chang-Il Kim, Kyu Seok Son, Jun Sik Joung, Yoon Ki 2024-01-19T10:32:41Z 2024-01-19T10:32:41Z 2023-01-03 2022-12 0167-577X https://pubs.kist.re.kr/handle/201004/114225 A series of dexamethasone (DEX)-loaded polydioxanone (PDO) monofilaments drawn at different draw ratios through a melt spinning process was developed to investigate changes in drug release behavior, mechanical properties, and biodegradation. Drawn PDO monofilaments presented decreased diameters, increased tensile strengths, and reduced elongation at break. The XRD analysis of DEX-loaded PDO monofilament showed changes in crystallinity due to the drawing process. The drawing process also changed behaviors of degradation and drug release, showing reduced degradation rates and long-term sustained release rates at higher draw ratios. Taken together, obtained characteristic properties and their controllability are expected to be favorable for practical applications requiring invasive and longer implantation such as non-vascular stents, surgical sutures, and facelifting materials. English Elsevier BV Effect of drawing on mechanical properties, degradation and drug release of dexamethasone-loaded polydioxanone monofilaments Article 10.1016/j.matlet.2022.133111 1 Materials Letters, v.328 Materials Letters 328 Y scie scopus 000895937500004 2-s2.0-85137174268 Materials Science, Multidisciplinary Physics, Applied Materials Science Physics Article Polydioxanone Monofilament Dexamethasone Drawing process