Kim, Juyeong Lee, Jae Kyun Moon, Bongjin Lee, Ansoo 2024-01-19T10:32:43Z 2024-01-19T10:32:43Z 2023-01-03 2022-12 1523-7060 https://pubs.kist.re.kr/handle/201004/114227 A regioselective alkylation of beta,gamma-alkynyl-alpha-imino esters by visible-light photocatalysis has been developed. This method enables 1,2-addition of methyl, primary, secondary, and tertiary alkyl radicals to the conjugated imines under mild conditions to produce a variety of quaternary alkynyl alpha-amino acid and cyclic amino acid motifs. Alkyl radicals are generated from alkyl bis(catecholato)silicates with an organic photocatalyst. This process is effective under an air atmosphere, providing operational benefits compared to conventional alkylation using organometallic reagents. English American Chemical Society Photocatalytic Alkyl Addition to Access Quaternary Alkynyl alpha-Amino Esters Article 10.1021/acs.orglett.2c03669 1 Organic Letters, v.24, no.48, pp.8870 - 8874 Organic Letters 24 48 8870 8874 N scie scopus 000895810500001 2-s2.0-85142734978 Chemistry, Organic Chemistry Article RADICAL ALKYLATION INHIBITORS ETHYNYL DESIGN ACIDS