Lee, Wang Hee Rho, Jun Gi Yang, Yeyoung Lee, Seulbi Kweon, Sohui Kim, Hyung-Mo Yoon, Juhwan Choi, Hongseo Lee, Eunyoung Ha Kim, Su You, Sohee Song, Yujin Oh, Young Soo Kim, Hwan Han, Hwa Seung Han, Ji Hye Jung, Myeongwoo Park, Young Hwan Choi, Yang Seon Han, Sukyoung Lee, Junho Choi, Sangdun Kim, Jung-Woong Park, Jae Hyung Lee, Eun Kyung Song, Woo Keun Kim, Eunha Kim, Wook 2024-01-19T10:32:59Z 2024-01-19T10:32:59Z 2022-12-09 2022-12 1936-0851 https://pubs.kist.re.kr/handle/201004/114239 Although conventional topical approaches for treating psoriasis have been offered as an alternative, there are still unmet medical needs such as low skin-penetrating efficacy and off-target adverse effects. A hyaluronic acid nanoparticle (HA-NP) formed by self-assembly of HA-hydrophobic moiety conjugates has been broadly studied as a nanocarrier for longterm and target-specific delivery of drugs, owing to their excellent physicochemical and biological characteristics. Here, we identify HA-NPs as topical therapeutics for treating psoriasis using in vivo skin penetration studies and psoriasis animal models. Transcutaneously administered HA-NPs were found to be accumulated and associated with pro-inflammatory macrophages in the inflamed dermis of a psoriasis mouse model. Importantly, HA-NP exerted potent therapeutic efficacy against psoriasis-like skin dermatitis in a size-dependent manner by suppressing innate immune responses and restoring skin barrier function without overt toxicity signs. The therapeutic efficacy of HA-NPs on psoriasis-like skin dermatitis was due to the outermost hydrophilic HA shell layer of HA-NPs, independent of the molecular weight of HA and hydrophobic moiety, and comparable with that of other conventional psoriasis therapeutics widely used in the clinical settings. Overall, HA-NPs have the potential as a topical nanomedicine for treating psoriasis effectively and safely. English American Chemical Society Hyaluronic Acid Nanoparticles as a Topical Agent for Treating Psoriasis Article 10.1021/acsnano.2c07843 1 ACS Nano, v.16, no.12, pp.20057 - 20074 ACS Nano 16 12 20057 20074 N scie scopus 000886816900001 2-s2.0-85142313510 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Article EPIDERMAL BARRIER TIGHT JUNCTIONS SKIN MACROPHAGES MODEL DIFFERENTIATION DRUG psoriasis hyaluronic acid self-assembled nanoparticle skin barrier function skin inflammation topical therapeutics