Jeena, M. T. Jin, Seongeon Jeong, Keunsoo Cho, Yuri Kim, Jin Chul Lee, Jeong Hyeon Lee, Seokyoung Hwang, Suk-Won Kwak, Sang Kyu Kim, Sehoon Ryu, Ja-Hyoung 2024-01-19T10:33:37Z 2024-01-19T10:33:37Z 2022-10-13 2022-12 1616-301X https://pubs.kist.re.kr/handle/201004/114264 Intramitochondrial supramolecular assembly can be a new therapeutic strategy for treating cancer because mitochondria are the key for virtually all facets of the tumorigenesis. However, the in vivo applications of mitochondria-targeting molecules are limited due to the positive charge and hydrophobicity that should be possessed by these molecules to penetrate the mitochondrial membrane, which may induce nonspecific serum protein interactions and normal cell accumulation. Herein, a stimuli-responsive mitochondria-targeting molecule, Mito-SA that forms nano-sized micelles under physiological conditions is presented. In the aggregated state, the succinic amide bonds in Mito-SA are cleaved in response to tumoral pH by stabilizing the transition state through the intermolecular interactions and the micelle disassembles into a mitochondria-targeting parent molecule, Mito-FF. The Mito-FF accumulate inside cancer mitochondria to induce cell death by intra-mitochondrial self-assembly into fiber structures. This tumoral stimuli-responsive disassembly-assembly approach will provide insight to develop mitochondria targeted supramolecular anticancer agent with high tumoral specificity. English John Wiley & Sons Ltd. Cancer-Selective Supramolecular Chemotherapy by Disassembly-Assembly Approach Article 10.1002/adfm.202208098 1 Advanced Functional Materials, v.32, no.52 Advanced Functional Materials 32 52 N scie scopus 000863025700001 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article MOLECULES MECHANISM PEPTIDES DYNAMICS CELLS assembly-disassembly cancer cell death enhanced specificities intra-mitochondrial assemblies pH stimuli