Lee, Geumbee Ray, Emily Yoon, Hong -Joon Genovese, Sabrina Choi, Yeon Sik Lee, Min-Kyu Sahin, Samet Yan, Ying Ahn, Hak-Young Bandodkar, Amay J. Kim, Joohee Park, Minsu Ryu, Hanjun Kwak, Sung Soo Jung, Yei Hwan Odabas, Arman Khandpur, Umang Ray, Wilson Z. MacEwan, Matthew R. Rogers, John A. 2024-01-19T11:01:19Z 2024-01-19T11:01:19Z 2022-11-16 2022-10 2375-2548 https://pubs.kist.re.kr/handle/201004/114447 Local electrical stimulation of peripheral nerves can block the propagation of action potentials, as an attractive alternative to pharmacological agents for the treatment of acute pain. Traditional hardware for such purposes, however, involves interfaces that can damage nerve tissue and, when used for temporary pain relief, that impose costs and risks due to requirements for surgical extraction after a period of need. Here, we introduce a bioresorb-able nerve stimulator that enables electrical nerve block and associated pain mitigation without these drawbacks. This platform combines a collection of bioresorbable materials in architectures that support stable blocking with minimal adverse mechanical, electrical, or biochemical effects. Optimized designs ensure that the device disap-pears harmlessly in the body after a desired period of use. Studies in live animal models illustrate capabilities for complete nerve block and other key features of the technology. In certain clinically relevant scenarios, such approaches may reduce or eliminate the need for use of highly addictive drugs such as opioids. English American Association for the Advancement of Science A bioresorbable peripheral nerve stimulator for electronic pain block Article 10.1126/sciadv.abp9169 1 Science Advances, v.8, no.40 Science Advances 8 40 Y scie scopus 000872371400004 Multidisciplinary Sciences Science & Technology - Other Topics Article CONDUCTION BLOCK CUFF ELECTRODE ELECTRICAL-STIMULATION PRESCRIPTION OPIOID OVERDOSE