Lee, Ju Young Park, Sang Hoon Kim, Yujin Cho, Young Uk Park, Jaejin Hong, Jung-Hoon Kim, Kyubeen Shin, Jongwoon Ju, Jeong Eun Min, In Sik Sang, Mingyu Shin, Hyogeun Jeong, Ui-Jin Gao, Yuyan Li, Bowen Zhumbayeva, Aizhan Kim, Kyung Yeun Hong, Eun-Bin Nam, Min-Ho Jeon, Hojeong Jung, Youngmee Cheng, Huanyu Cho, Il-Joo Yu, Ki Jun 2024-01-19T11:01:20Z 2024-01-19T11:01:20Z 2022-11-16 2022-10 2397-4621 https://pubs.kist.re.kr/handle/201004/114448 Challenges in the understanding of three-dimensional (3D) brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to the difficulties of constructing mechanical design and spatial limitations of the implanted sites. Here, we present a foldable and flexible 3D neural prosthetic that facilitates the 3D mapping of complex neural circuits with high spatiotemporal dynamics from the intracortical to cortical region. This device is the tool to map the 3D neural transmission through sophisticatedly designed four flexible penetrating shanks and surface electrode arrays in one integrated system. We demonstrate the potential possibilities of identifying correlations of neural activities from the intracortical area to cortical regions through continuous monitoring of electrophysiological signals. We also exploited the structural properties of the device to record synchronized signals of single spikes evoked by unidirectional total whisker stimulation. This platform offers opportunities to clarify unpredictable 3D neural pathways and provides a next-generation neural interface. English Nature Publishing Group Foldable three dimensional neural electrode arrays for simultaneous brain interfacing of cortical surface and intracortical multilayers Article 10.1038/s41528-022-00219-y 1 npj Flexible Electronics, v.6, no.1 npj Flexible Electronics 6 1 Y scie scopus 000874945800002 Engineering, Electrical & Electronic Materials Science, Multidisciplinary Engineering Materials Science Article MICROPROBE SU-8 LARGE-SCALE MESOSTRUCTURES MULTICHANNEL