Jalani, Hitesh B. Sivaraman, Aneesh Min, Kyoung Ho Lee, Hwa Young Oh, Na Kyoung Kang, Hyeseul Keum, Gyochang Choi, Yongseok Lee, Kyeong 2024-01-19T11:30:13Z 2024-01-19T11:30:13Z 2022-08-11 2022-09 1463-9262 https://pubs.kist.re.kr/handle/201004/114727 An expeditious one-pot method for the synthesis of highly substituted 5-aminoimidazoles from glyoxals, anilines, and amidines was evaluated under metal/catalyst-free conditions operative at room temperature. The present protocol constitutes an environmentally friendly approach for the synthesis of highly substituted 5-aminoimidazoles, which are important building blocks of several bioactive and medicinal compounds. The readily and commercially available starting materials can be quickly assembled into imidazoles using this protocol and scaling up this process does not require chromatographic purification. Additionally, the reaction of 5-aminoimidazole with 2-bromobenzoyl chloride can provide a novel imidazo[5,1-b]quinazolin-9(4H)-one, thus showcasing the applicability of this protocol. English Royal Society of Chemistry Metal/catalyst-free sequential C-N bond forming cascades at room temperature: environment-friendly one-pot synthesis of 5-aminoimidazoles from aryl glyoxals, anilines, and amidines Article 10.1039/d2gc01407f 1 Green Chemistry, v.24, no.17, pp.6501 - 6510 Green Chemistry 24 17 6501 6510 N scie scopus 000831274600001 Chemistry, Multidisciplinary Green & Sustainable Science & Technology Chemistry Science & Technology - Other Topics Article MULTICOMPONENT SYNTHESIS IMIDAZOLE DERIVATIVES HETEROCYCLES RECEPTORS ALKALOIDS CHEMISTRY CONCISE INDOLE ACID