Kim, Youngseok Ju, Ha-Neul Choi, Pilju Kim, Taejung Park, Young-Tae Lee, Dae-Hee Ham, Jungyeob 2024-01-19T11:31:03Z 2024-01-19T11:31:03Z 2022-04-03 2022-09 1307-6167 https://pubs.kist.re.kr/handle/201004/114769 The compounds hydrangenol and hydrangenol 8-O-glucoside are abundant in Hydrangea macrophylla. This study investigated the effects of hydrangenol and hydrangenol 8-O-glucoside derived from H. macrophylla on atopic dermatitis (AD). Compared with hydrangenol 8-O-glucoside, hydrangenol resulted in more potent inhibition of interleukin 4 (IL-4) gene expression and beta-hexosaminidase release, as well as more potent inhibition of the phosphorylation of signal transducer and activator of transcription 6 (STAT6). Ultra High-Performance Liquid Chromatography (UHPLC), the concentrations of hydrangenol were found to be lower than the concentration of hydrangenol 8-O-glucoside in H. macrophylla extracts. To increase the hydrangenol content of H. macrophylla extract, component conversion methods were studied. Conclusion, microwave processing was found to be the optimal method for deglycosylation. English ACG Publications Improved Anti-Atopic Dermatitis Effect of H. macrophylla through the Generation of Hydrangenol by Microwave Processing Article 10.25135/rnp.298.21.10.2250 1 Records of Natural Products, v.16, no.5, pp.433 - 442 Records of Natural Products 16 5 433 442 N scie scopus 000734871200001 Plant Sciences Chemistry, Applied Chemistry, Medicinal Plant Sciences Chemistry Pharmacology & Pharmacy Article VAR. THUNBERGII HISTAMINE-RELEASE LEAVES CONSTITUENTS ENHANCEMENT EXPRESSION Hydrangea macrophylla hydrangenol hydrangenol 8-O-glucoside atopic dermatitis microwave irradiation