Maccioni, Paola Colombo, Giancarlo Lorrai, Irene Lee, Jung Hwan Pel, Pisey Chin, Young-Won Kwon, Hak Cheol 2024-01-19T11:31:06Z 2024-01-19T11:31:06Z 2022-01-10 2022-09 1478-6419 https://pubs.kist.re.kr/handle/201004/114772 Recent studies demonstrated that saikosaponin (SS) A and other SSs extracted from Bupleurum falcatum L. (Apiaceae) roots abolished different behaviours motivated by drugs of abuse and palatable foods in rats. The present study was designed to investigate the effect of an SS-enriched extract fraction of B. falcatum roots on operant, oral self-administration of alcohol and chocolate in rats. To this end, female Sardinian alcohol-preferring and Wistar rats were trained to lever-respond for alcohol (15% v/v) and chocolate (5% w/v powdered Nesquik in water), respectively. Acute treatment with B. falcatum extract (0, 0.75, 1.5, and 3 mg/kg, i.p.) reduced, in a dose-related manner, both alcohol and chocolate self-administration. These data confirm the notion that B. falcatum extracts may be a valuable source of pharmacological agents with anti-addictive and anorectic potential. The use of experimental procedures with predictive validity for the human disease adds strength to the translational potential of these results. English Taylor & Francis Suppressing effect of a saikosaponin-enriched extract of Bupleurum falcatum on alcohol and chocolate self-administration in rats Article 10.1080/14786419.2021.1986816 1 Natural Product Research, v.36, no.17, pp.4502 - 4505 Natural Product Research 36 17 4502 4505 N scie scopus 000706229100001 2-s2.0-85116761685 Chemistry, Applied Chemistry, Medicinal Chemistry Pharmacology & Pharmacy Article Bupleurum falcatum L extract saikosaponin A saikosaponins alcohol self-administration chocolate self-administration rat