Badadhe, Jaya Dilip Roh, Hyeonhee Lee, Byung Chul Kim, Jae Hun Im, Maesoon 2024-01-19T11:31:34Z 2024-01-19T11:31:34Z 2022-09-02 2022-08 1662-5102 https://pubs.kist.re.kr/handle/201004/114796 Globally, it is estimated there are more than 2.2 billion visually impaired people. Visual diseases such as retinitis pigmentosa, age-related macular degeneration, glaucoma, and optic neuritis can cause irreversible profound vision loss. Many groups have investigated different approaches such as microelectronic prostheses, optogenetics, stem cell therapy, and gene therapy to restore vision. However, these methods have some limitations such as invasive implantation surgery and unknown long-term risk of genetic manipulation. In addition to the safety of ultrasound as a medical imaging modality, ultrasound stimulation can be a viable non-invasive alternative approach for the sight restoration because of its ability to non-invasively control neuronal activities. Indeed, recent studies have demonstrated ultrasound stimulation can successfully modulate retinal/brain neuronal activities without causing any damage to the nerve cells. Superior penetration depth and high spatial resolution of focused ultrasound can open a new avenue in neuromodulation researches. This review summarizes the latest research results about neural responses to ultrasound stimulation. Also, this work provides an overview of technical viewpoints in the future design of a miniaturized ultrasound transducer for a non-invasive acoustic visual prosthesis for non-surgical and painless restoration of vision. English Frontiers Media S.A. Ultrasound stimulation for non-invasive visual prostheses Article 10.3389/fncel.2022.971148 1 Frontiers in Cellular Neuroscience, v.16 Frontiers in Cellular Neuroscience 16 Y scie scopus 000841301300001 Neurosciences Neurosciences & Neurology Review INTENSITY FOCUSED ULTRASOUND PHASED-ARRAY SYSTEM RESPONSES CHANNELS CELLS ultrasound stimulation neuromodulation artificial vision vision restoration visual prosthesis