Kim, Seongchan Oh, Taegon Lee, Hyojin Nam, Jwa-Min 2024-01-19T11:32:31Z 2024-01-19T11:32:31Z 2022-06-17 2022-08 https://pubs.kist.re.kr/handle/201004/114838 Many policies, including the European Green Deal, have been released to enhance global economic sustainability. Such policies require new materials to be sustainable, cost-effective, and safe for the fabrication of products that comply with regulations and are acceptable to consumers. In this context, the field of bionanomaterials has shifted toward developing green synthesis methods and the use of sustainable and eco-friendly materials. All these have to be considered for clinical applications along with other key issues and challenges in biomedical science including highly efficient targeted delivery of materials and chemicals with minimal toxicity and side effects. Here, we review the various types of inorganic and organic nanoparticles (NPs) used as the delivery vehicles to specific sites in human bodies, and discuss their advantageous properties and functions along with issues and limitations for clinical therapeutic applications. We summarized the strategies that can overcome both biological barriers such as the blood-brain barrier and harsh physiological conditions to realize clinically meaningful delivery systems, and introduced and discussed green synthesis methods for NPs and their environmental impacts. Finally, the perspectives on the biocompatibility, toxicity and environmental consequences of these NPs developed for biomedical applications are provided. English ROYAL SOC CHEMISTRY Trends and perspectives in bio- and eco-friendly sustainable nanomaterial delivery systems through biological barriers Article 10.1039/d2qm00039c 1 Materials Chemistry Frontiers, v.6, no.16, pp.2152 - 2174 Materials Chemistry Frontiers 6 16 2152 2174 N scie scopus 000807096300001 Chemistry, Multidisciplinary Materials Science, Multidisciplinary Chemistry Materials Science Review ANATASE TIO2 NANOPARTICLES GEL-SOL METHOD NANOSTRUCTURED LIPID CARRIERS SUPERCRITICAL CARBON-DIOXIDE SHAPE-CONTROLLED SYNTHESIS GREEN SYNTHESIS GOLD NANOPARTICLES DRUG-DELIVERY SILVER NANOPARTICLES INTRACELLULAR SYNTHESIS