임태환 이기욱 김련희 차광현 구송이 문은채 황금택 2024-01-19T11:32:59Z 2024-01-19T11:32:59Z 2022-10-18 2022-07 1226-7708 https://pubs.kist.re.kr/handle/201004/114859 Blood trimethylamine-N-oxide (TMAO) has been associated with cardiovascular disease. Black raspberry (Rubus occidentalis, BR) has been regarded to be beneficial for cardiovascular health. This study aimed to investigate how BR extract affects serum lipid profile, gut microbial composition, metabolites in rats fed TMAO with a high-fat diet. Dietary TMAO increased serum LDL cholesterol, while BR extract decreased its level. α-Diversity of gut microbiota was not changed; however, in the rats fed TMAO, Macellibacteroides and Mucispirillum were enriched, while Ruminococcaceae was reduced. The BR supplementation could restore Macellibacteroides, Clostridium, and Ruminococcaceae. The BR supplementation increased cecal hippuric acid and serum farnesoid X receptor-antagonistic bile acids, including ursodeoxycholic acid (UDCA), tauro-α-muricholic acid, and tauro-UDCA. The BR supplementation tended to upregulate Cyp7a1 and Abcg5 expressions while downregulating Srebf2 and Hmgcr expressions. BR extract affects the gut bacterial community and microbial metabolites, lowering serum LDL cholesterol in rats with elevated serum TMAO. English 한국식품과학회 Black raspberry extract can lower serum LDL cholesterol via modulation of gut microbial composition and serum bile acid profile in rats fed trimethylamine-N-oxide with a high-fat diet Article 10.1007/s10068-022-01079-y 1 Food Science and Biotechnology, v.31, no.8, pp.1041 - 1051 Food Science and Biotechnology 31 8 1041 1051 N scie scopus kci ART002862816 000779987000001 2-s2.0-85127745116 Black raspberry Trimethylamine-N-oxide Gut microbiota FXR-antagonistic bile acid Hippuric acid