Seitkazina, Assel Kim, Kyu Hyeon Fagan, Erin Sung, Yoonsik Kim, Yun Kyung Lim, Sungsu 2024-01-19T11:33:16Z 2024-01-19T11:33:16Z 2022-08-11 2022-07 https://pubs.kist.re.kr/handle/201004/114874 Neuronal accumulation of mis-folded tau is the pathological hallmark of multiple neurodegenerative disorders, including Alzheimer’s disease. Distinct from amyloid plaques, which appear simultaneously throughout the brain, tau pathology develops first in a specific brain region and then propagates to neuroanatomically connected brain regions, exacerbating the disease. Due to the implication in disease progression, prevention of tau transmission is recognized as an important therapeutic strategy that can halt disease progression in the brain. Recently, accumulating studies have demonstrated diverse cellular mechanisms associated with cell-to-cell transmission of tau. Once transmitted, mis-folded tau species act as a prion-like seed for native tau aggregation in the recipient neuron. In this review, we summarize the diverse cellular mechanisms associated with the secretion and uptake of tau, and highlight tau-trafficking receptors, which mediate tau clearance or cell-to-cell tau transmission. English Frontiers Media S.A. The Fate of Tau Aggregates Between Clearance and Transmission Article 10.3389/fnagi.2022.932541 1 Frontiers in Aging Neuroscience, v.14 Frontiers in Aging Neuroscience 14 Y scie scopus 000834550300001 Geriatrics & Gerontology Neurosciences Geriatrics & Gerontology Neurosciences & Neurology Review CEREBROSPINAL-FLUID EXTRACELLULAR TAU ALZHEIMERS-DISEASE HUMAN NEURONS AUTOPHAGIC DEGRADATION TUNNELING NANOTUBES COGNITIVE DECLINE AXONAL-TRANSPORT TANGLE PATHOLOGY ENDOGENOUS TAU tau tau clearance tau transmission tauopathy pathological tau