Kim, Tae-Young Park, No-June Jo, Beom-Geun Paik, Jin-Hyub Choi, Sangho Kim, Su-Nam Yang, Min Hye 2024-01-19T11:33:18Z 2024-01-19T11:33:18Z 2022-08-11 2022-07 2076-3921 https://pubs.kist.re.kr/handle/201004/114876 7-O-methylluteolin (7-ML) is a flavonoid isolated from the aerial parts of Wikstroemia ganpi (W. ganpi). We describe the anti-atopic dermatitis (AD) effects of 7-ML in tert-butyl hydroperoxide (tBHP)-induced HepG2 cells and 2,4-dinitrochlorobenzene (DNCB)-induced SKH-1 hairless mice. Results demonstrated that 7-ML dose-dependently inhibited the activation of Nrf2 (nuclear factor-erythroid 2-related factor 2) in tBHP-induced HepG2 cells. 7-ML applied topically to our DNCB-induced mouse model upregulated the antioxidant protein expression (phosphorylated Nrf2 (pNrf2), Nrf2, and heme oxygenase-1 (HO-1)) in skin tissues, improved epidermal thickness, and reduced mast cell infiltration into the skin. In addition, 7-ML reduced the serum levels of immunoglobulin E (IgE) and interleukin-4 (IL-4) and improved skin barrier functions. These results suggest that 7-ML should be considered a novel antioxidant and anti-AD agent. English MDPI AG 7-O-Methylluteolin Suppresses the 2,4-Dinitrochlorobenzene-Induced Nrf2/HO-1 Pathway and Atopic Dermatitis-like Lesions Article 10.3390/antiox11071344 1 Antioxidants, v.11, no.7 Antioxidants 11 7 Y scie scopus 000833672800001 Biochemistry & Molecular Biology Chemistry, Medicinal Food Science & Technology Biochemistry & Molecular Biology Pharmacology & Pharmacy Food Science & Technology Article FLAVONOIDS LUTEOLIN COMPONENTS MODULATION L. Wikstroemia ganpi 7-O-methylluteolin atopic dermatitis antioxidant anti-inflammation