Lee, Jinkyung Kim, Suhyun Kim, Yoon Hwan Park, Uiyeol Lee, Junghee McKee, Ann C. Kim, Kyoung Heon Ryu, Hoon Lee, Jeongae 2024-01-19T11:33:19Z 2024-01-19T11:33:19Z 2022-08-11 2022-07 2227-9059 https://pubs.kist.re.kr/handle/201004/114877 Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that is frequently found in athletes and those who have experienced repetitive head traumas. CTE is associated with a variety of neuropathologies, which cause cognitive and behavioral impairments in CTE patients. However, currently, CTE can only be diagnosed after death via brain autopsy, and it is challenging to distinguish it from other neurodegenerative diseases with similar clinical features. To better understand this multifaceted disease and identify metabolic differences in the postmortem brain tissues of CTE patients and control subjects, we performed ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS)-based non-targeted metabolomics. Through multivariate and pathway analysis, we found that the brains of CTE patients had significant changes in the metabolites involved in astrocyte activation, phenylalanine, and tyrosine metabolism. The unique metabolic characteristics of CTE identified in this study were associated with cognitive dysfunction, amyloid-beta deposition, and neuroinflammation. Altogether, this study provided new insights into the pathogenesis of CTE and suggested appealing targets for both diagnosis and treatment for the disease. English MDPI AG Non-Targeted Metabolomics Approach Revealed Significant Changes in Metabolic Pathways in Patients with Chronic Traumatic Encephalopathy Article 10.3390/biomedicines10071718 1 Biomedicines, v.10, no.7 Biomedicines 10 7 Y scie scopus 000833363200001 Biochemistry & Molecular Biology Medicine, Research & Experimental Pharmacology & Pharmacy Biochemistry & Molecular Biology Research & Experimental Medicine Pharmacology & Pharmacy Article D-SERINE BRAIN-INJURY REACTIVE ASTROCYTES TYROSINE DISEASE PHENYLALANINE PHENYLKETONURIA NOREPINEPHRINE NEUROPATHOLOGY NEUROMELANIN chronic traumatic encephalopathy (CTE) non-targeted metabolomics astrocyte activation catecholamines tyrosine metabolism phenylalanine metabolism