Nanda, Sitansu Sekhar Wang, Tuntun Hossain, Md Imran Yoon, Hong Yeol Selvan, Subramanian Tamil Kim, Kwangmeyung Yi, Dong Kee 2024-01-19T12:00:23Z 2024-01-19T12:00:23Z 2022-07-14 2022-06 2574-0970 https://pubs.kist.re.kr/handle/201004/115102 Controlling local and systemic factors during the wound-healing process, including inflammation, proliferation, and maturation, can play a key role in effective wound healing. It is worth taking advantage of matrix-or scaffold-based therapeutic approaches. Herein, a gold nanorod (GNR)-incorporated poly(lactic-co-glycolic acid) (PLGA)/poly(caprolactone) (PCL) scaffold was developed to improve the wound-healing effect by controlling heat shock protein (HSP70) via external light stimulation. The GNR-incorporated scaffold showed no harmful effects on the cells and could stimulate cell proliferation in vitro by generating mild heat generation in a timely manner with laser irradiation. A GNR-incorporated scaffold attached to the wound of mice effectively increased the local temperature to 40 degrees C after laser irradiation, more effectively promoting HSP70 expression and the wound-healing process compared to that of conventional dressing-and scaffold-treated mice. The GNR-incorporated scaffold and timely control HSP70 expression approach can be used as a promising wound-healing strategy for improving the therapeutic effect. English American Chemical Society Gold-Nanorod-Based Scaffolds for Wound-Healing Applications Article 10.1021/acsanm.2c02230 1 ACS Applied Nano Materials, v.5, no.6, pp.8640 - 8648 ACS Applied Nano Materials 5 6 8640 8648 N scie scopus 000820483800001 Nanoscience & Nanotechnology Materials Science, Multidisciplinary Science & Technology - Other Topics Materials Science Article; Early Access HEAT-SHOCK PROTEINS STEM-CELLS ANTIBACTERIAL ACTIVITY SKIN NANOPARTICLES MECHANISM DRESSINGS STRESS UNIT gold nanorod PLGA/PCL scaffold HSP wound healing H&E staining