Al Mazid, Mohammad Faysal Park, Seung Bin Cheekatla, Subba Rao Murale, Dhiraj P. Shin, Kyung Ho Lee, Jun-Seok 2024-01-19T12:01:04Z 2024-01-19T12:01:04Z 2022-06-23 2022-06 1661-6596 https://pubs.kist.re.kr/handle/201004/115140 Chemical probes can be used to understand the complex biological nature of diseases. Due to the diversity of cancer types and dynamic regulatory pathways involved in the disease, there is a need to identify signaling pathways and associated proteins or enzymes that are traceable or detectable in tests for cancer diagnosis and treatment. Currently, fluorogenic chemical probes are widely used to detect cancer-associated proteins and their binding partners. These probes are also applicable in photodynamic therapy to determine drug efficacy and monitor regulating factors. In this review, we discuss the synthesis of chemical probes for different cancer types from 2016 to the present time and their application in monitoring the activity of transferases, hydrolases, deacetylases, oxidoreductases, and immune cells. Moreover, we elaborate on their potential roles in photodynamic therapy. English Multidisciplinary Digital Publishing Institute (MDPI) Chemical Probes and Activity-Based Protein Profiling for Cancer Research Article 10.3390/ijms23115936 1 International Journal of Molecular Sciences, v.23, no.11 International Journal of Molecular Sciences 23 11 Y scie scopus 000809182400001 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Review GLUTATHIONE-S-TRANSFERASE FLUORESCENT-PROBE PHOTODYNAMIC THERAPY NITRIC-OXIDE TARGET activity-based probe near-infrared probe photodynamic therapy