Voroslakos, Mihaly Kim, Kanghwan Slager, Nathan Ko, Eunah Oh, Sungjin Parizi, Saman S. Hendrix, Blake Seymour, John P. Wise, Kensall D. Buzsaki, Gyorgy Fernandez-Ruiz, Antonio Yoon, Euisik 2024-01-19T12:01:37Z 2024-01-19T12:01:37Z 2022-05-04 2022-06 2198-3844 https://pubs.kist.re.kr/handle/201004/115167 Dynamic interactions within and across brain areas underlie behavioral and cognitive functions. To understand the basis of these processes, the activities of distributed local circuits inside the brain of a behaving animal must be synchronously recorded while the inputs to these circuits are precisely manipulated. Even though recent technological advances have enabled such large-scale recording capabilities, the development of the high-spatiotemporal-resolution and large-scale modulation techniques to accompany those recordings has lagged. A novel neural probe is presented in this work that enables simultaneous electrical monitoring and optogenetic manipulation of deep neuronal circuits at large scales with a high spatiotemporal resolution. The "hectoSTAR" micro-light-emitting-diode (mu LED) optoelectrode features 256 recording electrodes and 128 stimulation mu LEDs monolithically integrated on the surface of its four 30-mu m thick silicon micro-needle shanks, covering a large volume with 1.3-mm x 0.9-mm cross-sectional area located as deep as 6 mm inside the brain. The use of this device in behaving mice for dissecting long-distance network interactions across cortical layers and hippocampal regions is demonstrated. The recording-and-stimulation capabilities hectoSTAR mu LED optoelectrodes enables will open up new possibilities for the cellular and circuit-based investigation of brain functions in behaving animals. English Wiley-VCH Verlag HectoSTAR mu LED Optoelectrodes for Large-Scale, High-Precision In Vivo Opto-Electrophysiology Article 10.1002/advs.202105414 1 Advanced Science, v.9, no.18 Advanced Science 9 18 Y scie scopus 000784473400001 Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Article LOCAL-FIELD POTENTIALS SILICON PROBES HIGH-DENSITY NEURAL CIRCUITS OPTICAL CONTROL PLACE CELLS REPLAY HIPPOCAMPUS SEQUENCES PERTURBATION mu LED large-scale optoelectrophysiology neural probe neuronal ensembles optogenetics