Rahman, Md. Ataur Rahman, MD. Hasanur Mamun-Or-Rashid, A. N. M. Hwang, Hongik Chung, Sooyoung Kim, Bonglee Rhim, Hyewhon 2024-01-19T12:02:25Z 2024-01-19T12:02:25Z 2022-06-09 2022-05 2227-9059 https://pubs.kist.re.kr/handle/201004/115204 Alzheimer's disease (AD) is one of the most prevailing neurodegenerative diseases in the world, which is characterized by memory dysfunction and the formation of tau and amyloid beta (A beta) aggregates in multiple brain regions, including the hippocampus and cortex. The formation of senile plaques involving tau hyperphosphorylation, fibrillar A beta, and neurofibrillary tangles (NFTs) is used as a pathological marker of AD and eventually produces aggregation or misfolded protein. Importantly, it has been found that the failure to degrade these aggregate-prone proteins leads to pathological consequences, such as synaptic impairment, cytotoxicity, neuronal atrophy, and memory deficits associated with AD. Recently, increasing evidence has suggested that the autophagy pathway plays a role as a central cellular protection system to prevent the toxicity induced by aggregation or misfolded proteins. Moreover, it has also been revealed that AD-related protein aggresomes could be selectively degraded by autophagosome and lysosomal fusion through the autophagy pathway, which is known as aggrephagy. Therefore, the regulation of autophagy serve as a useful approach to modulate the formation of aggresomes associated with AD. This review focuses on the recent improvements in the application of natural compounds and small molecules as a potential therapeutic approach for AD prevention and treatment via aggrephagy. English MDPI AG Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer's Disease Article 10.3390/biomedicines10051027 1 Biomedicines, v.10, no.5 Biomedicines 10 5 Y scie scopus 000801773000001 Biochemistry & Molecular Biology Medicine, Research & Experimental Pharmacology & Pharmacy Biochemistry & Molecular Biology Research & Experimental Medicine Pharmacology & Pharmacy Review HISTONE DEACETYLASE 6 TAUOPATHY IN-VITRO NEURODEGENERATIVE DISEASES THERAPEUTIC TARGET INCLUSION-BODIES MOUSE MODEL PROTEINS CELLS TAU DEGRADATION autophagy aggresome autophagosomes aggrephagy Alzheimer&apos s disease (AD) aggregation