Artan, Murat Sohn, Jooyeon Lee, Cheolju Park, Seung-Yeol Lee, Seung-Jae, V 2024-01-19T12:03:19Z 2024-01-19T12:03:19Z 2022-04-05 2022-05 1554-8627 https://pubs.kist.re.kr/handle/201004/115251 The Golgi apparatus regulates the process of modification and subcellular localization of macromolecules, including proteins and lipids. Aberrant protein sorting caused by defects in the Golgi leads to various diseases in mammals. However, the role of the Golgi apparatus in organismal longevity remained largely unknown. By employing a quantitative proteomic approach, we demonstrated that MON-2, an evolutionarily conserved Arf-GEF protein implicated in Golgi-to-endosome trafficking, promotes longevity via upregulating macroautophagy/autophagy in C. elegans. Our data using cultured mammalian cells indicate that MON-2 translocates from the Golgi to the endosome under starvation conditions, subsequently increasing autophagic flux by binding LGG-1/GABARAPL2. Thus, Golgi-to-endosome trafficking appears to be an evolutionarily conserved process for the upregulation of autophagy, which contributes to organismal longevity. English Landes Bioscience MON-2, a Golgi protein, promotes longevity by upregulating autophagy through mediating inter-organelle communications Article 10.1080/15548627.2022.2039523 1 Autophagy, v.18, no.5, pp.1208 - 1210 Autophagy 18 5 1208 1210 N scie scopus 000758859600001 2-s2.0-85125803513 Cell Biology Cell Biology Editorial Material Aging autophagy C. elegans Golgi LGG-1/GABARAPL2 lifespan MON-2/MON2 proteomics