Nam, Min-Ho Sa, Moonsun Ju, Yeon Ha Park, Mingu Gordon Lee, C. Justin 2024-01-19T12:04:29Z 2024-01-19T12:04:29Z 2022-05-04 2022-04 1661-6596 https://pubs.kist.re.kr/handle/201004/115310 Monoamine oxidase-B (MAOB) has been believed to mediate the degradation of monoamine neurotransmitters such as dopamine. However, this traditional belief has been challenged by demonstrating that it is not MAOB but MAOA which mediates dopamine degradation. Instead, MAOB mediates the aberrant synthesis of GABA and hydrogen peroxide (H2O2) in reactive astrocytes of Parkinson's disease (PD). Astrocytic GABA tonically suppresses the dopaminergic neuronal activity, whereas H2O2 aggravates astrocytic reactivity and dopaminergic neuronal death. Recently discovered reversible MAOB inhibitors reduce reactive astrogliosis and restore dopaminergic neuronal activity to alleviate PD symptoms in rodents. In this perspective, we redefine the role of MAOB for the aberrant suppression and deterioration of dopaminergic neurons through excessive GABA and H2O2 synthesis of reactive astrocytes in PD. English Multidisciplinary Digital Publishing Institute (MDPI) Revisiting the Role of Astrocytic MAOB in Parkinson's Disease Article 10.3390/ijms23084453 1 International Journal of Molecular Sciences, v.23, no.8 International Journal of Molecular Sciences 23 8 Y scie scopus 000786079500001 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Review MONOAMINE-OXIDASE-B TONIC GABA RELEASE IN-VIVO DOPAMINE TRANSPORTER SUBSTANTIA-NIGRA RAT-BRAIN INHIBITION METABOLISM DEAMINATION MPTP astrocyte Parkinson&apos s disease MAOB GABA H2O2 dopamine