Garza, Hector Hugo Perez Ghatkesar, Murali Krishna Staufer, Urs Manz, Andreas Lothman, Per 2024-01-19T12:08:10Z 2024-01-19T12:08:10Z 2022-03-01 2014-04 2474-3747 https://pubs.kist.re.kr/handle/201004/115363 We demonstrate local synthesis and deposition of gold nanoparticles (AuNPs) using a femtopipette, which is a device similar to an atomic force microscope (AFM) sensor but featuring integrated fluidic channels. Two femtopipettes were used, one filled with chloroauric-acid (HAuCl4), and the second with sodium-azide (NaN3). We dispensed two equal droplets (HAuCl4 and NaN3) adjacent to each other, allowing them to coalesce and mix. In this manner, cross-contamination between the tips was prevented. The deposited volumes (per reagent) were 2.4fL, 1.2fL, 0.5fL and 0.25fL. Upon mixture, a chemical reduction process was triggered, which led to the local formation of AuNPs. The performed analysis indicate that the size of the nanoparticles is dominated by droplet volume. For the biggest droplet-mixture, the dominant particle size was 14nm. Whereas for the smallest droplets, the dominant particle size was 4nm. Similarly, the size distribution decreased with smaller droplet volumes. To the best of our knowledge, the combination of deposition and local chemistry using femtoliter-droplets, has not been reported before and represents a new level of compartmentalized nanoparticle synthesis and positioning. English IEEE Enabling Local Deposition and Controlled Synthesis of Au-Nanoparticles Using a Femtopipette Conference 2 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS), pp.323 - 328 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) 323 328 US Honolulu, HI 2014-04-13 2014 9TH IEEE INTERNATIONAL CONFERENCE ON NANO/MICRO ENGINEERED AND MOLECULAR SYSTEMS (NEMS) 000361044400072